Miranda-Filho, A. & Bray, F. Global patterns and trends in cancers of the lip, tongue and mouth. Oral Oncol. 1(102), 104551 (2020).
Warnakulasuriya, S. & Kerr, A. R. Oral cancer screening: Past, present, and future. J. Dent. Res. 100(12), 1313–1320 (2021).
Rajendran, R. Shafer’s textbook of oral pathology (Elsevier India, 2009).
Amarasinghe, A. A., Usgodaarachchi, U. S., Johnson, N. W. & Warnakulasuriya, S. High prevalence of lifestyle factors attributable for oral cancer, and of oral potentially malignant disorders in rural Sri Lanka. Asian Pac. J. Cancer Prev.: APJCP 19(9), 2485 (2018).
Senevirathna, K., Jayasinghe, Y. A., Jayawickrama, S. M., Amarasinghe, H. & Jayasinghe, R. D. Oral cancer disease among the poor: A Sri Lankan context. Oral 3(3), 420–436 (2023).
Condoluci, A., Mazzara, C., Zoccoli, A., Pezzuto, A. & Tonini, G. Impact of smoking on lung cancer treatment effectiveness: A review. Future Oncol. 12(18), 2149–2161 (2016).
Koedrith, P., Kim, H., Weon, J. I. & Seo, Y. R. Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity. Int. J. Hyg. Environ. Health 216(5), 587–598 (2013).
Maret, W. The metals in the biological periodic system of the elements: Concepts and conjectures. Int. J. Mol. Sci.. 17(1), 66 (2016).
Tsai, K. Y., Su, C. C., Chiang, C. T., Tseng, Y. T. & Lian, I. B. Environmental heavy metal as a potential risk factor for the progression of oral potentially malignant disorders in central Taiwan. Cancer Epidemiol. 1(47), 118–124 (2017).
Viana, G. F., Garcia, K. S. & Menezes-Filho, J. A. Assessment of carcinogenic heavy metal levels in Brazilian cigarettes. Environ. Monit. Assess. 181, 255–265 (2011).
Wise, J. T., Wang, L., Zhang, Z. & Shi, X. The 9th conference on metal toxicity and carcinogenesis: The conference overview. Toxicol. Appl. Pharmacol. 15(331), 1–5 (2017).
IARC of WHO. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Last Updated: 2022–09–07. Available online: https://monographs.iarc.who.int/list-of-classifications (accessed on 17 March 2023)
Wu, X. et al. A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment. Environ. Sci. Pollut. Res. 23, 8244–8259 (2016).
Morales, M. E. et al. Heavy metal exposure influences double strand break DNA repair outcomes. PloS One 11(3), e0151367 (2016).
Fouani, L., Menezes, S. V., Paulson, M., Richardson, D. R. & Kovacevic, Z. Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents. Pharmacol. Res. 1(115), 275–287 (2017).
Ahmed, M. K., Habibullah-Al-Mamun, M., Parvin, E., Akter, M. S. & Khan, M. S. Arsenic induced toxicity and histopathological changes in gill and liver tissue of freshwater fish, tilapia (Oreochromis mossambicus). Exp. Toxicol. Pathol. 65(6), 903–909 (2013).
Tiwari, R. et al. Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer. Braz. Oral Res. 10(30), e101 (2016).
Sohrabi, M. et al. Trace element and heavy metal levels in colorectal cancer: Comparison between cancerous and non-cancerous tissues. Biol. Trace Element Res. 183, 1–8 (2018).
Formigari, A., Gregianin, E. & Irato, P. The effect of zinc and the role of p53 in copper-induced cellular stress responses. J. Appl. Toxicol. 33(7), 527–536 (2013).
Bocca, B. et al. Determination of 30 elements in colorectal biopsies by sector field inductively coupled plasma mass spectrometry: Method development and preliminary baseline levels. Rapid Comm. Mass Spectrom. 21(11), 1776–1782 (2007).
Bocca, B., Mattei, D., Pino, A. & Alimonti, A. Italian network for human biomonitoring of metals: Preliminary results from two regions. Annali dell’Istituto superiore di sanità 46, 259–265 (2010).
Baltaci, A. K., Dundar, T. K., Aksoy, F. & Mogulkoc, R. Changes in the serum levels of trace elements before and after the operation in thyroid cancer patients. Biol. Trace Elem. Res. 175, 57–64 (2017).
Saghiri, M. A., Asatourian, A., Orangi, J., Sorenson, C. M. & Sheibani, N. Functional role of inorganic trace elements in angiogenesis—Part I: N, Fe, Se, P, Au, and Ca. Crit. Rev. Oncol. Hematol. 96(1), 129–142 (2015).
Chiang, C. T. et al. A critical exploration of blood and environmental chromium concentration among oral cancer patients in an oral cancer prevalent area of Taiwan. Environ. Geochem. Health 33, 469–476 (2011).
Alimonti, A. et al. A study on metals content in patients with colorectal polyps. J. Toxicol. Environ. Health Part A 71(5), 342–347 (2008).
Rinaldi, L. et al. Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue. Dig. Liver Dis. 47(7), 602–607 (2015).
Cobalt and cobalt compounds. IARC Monogr. Eval. Carcinog. Risks Hum. 52, 363–472 (1991). PMID: 1960848; PMCID:
PMC7682369.
Lison, D., De Boeck, M., Verougstraete, V. & Kirsch-Volders, M. Update on the genotoxicity and carcinogenicity of cobalt compounds. Occup. Environ. Med. 58(10), 619–625 (2001).
Lison, D., Van Den Brûle, S. & Van Maele-Fabry, G. Cobalt and its compounds: Update on genotoxic and carcinogenic activities. Crit. Rev. Toxicol. 48(7), 522–539 (2018).
Zhang, B. et al. Evaluation of cadmium levels in dental calculus of male oral SCC patients with Betel-Quid Chewing in Hunan Province of China. Biol. Trace Elem. Research. 15(191), 348–353 (2019).
Talio, M. C., Luconi, M. O., Masi, A. N. & Fernández, L. P. Cadmium monitoring in saliva and urine as indicator of smoking addiction. Sci. Total Environ. 408(16), 3125–3132 (2010).
Tavakoli Pirzaman, A. et al. Toxic mechanisms of cadmium and exposure as a risk factor for oral and gastrointestinal carcinomas. Hum. Exp. Toxicol. 20(42), 09603271231210262 (2023).
Stohs, S. J., Bagchi, D., Hassoun, E. & Bagchi, M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 20(2), 12 (2001).
Drasch, G., Schöpfer, J. & Schrauzer, G. N. Selenium/cadmium ratios in human prostates: Indicators of prostate cancer risk of smokers and nonsmokers, and relevance to the cancer protective effects of selenium. Biol. Trace Elem. Res. 103, 103–107 (2005).
Schultze, B., Lind, P. M., Larsson, A. & Lind, L. Whole blood and serum concentrations of metals in a Swedish population-based sample. Scand. J. Clin. Lab. Investing. 74(2), 143–148 (2014).
Castiella, A. et al. Gender and plasma iron biomarkers, but not HFE gene mutations, increase the risk of colorectal cancer and polyps. Tumor Biol. 36(9), 6959–6963 (2015).
Qiao, L. & Feng, Y. Intakes of heme iron and zinc and colorectal cancer incidence: A meta-analysis of prospective studies. Cancer Causes Control 24, 1175–1183 (2013).
Spangler, J. G. & Reid, J. C. Environmental manganese and cancer mortality rates by county in North Carolina: An ecological study. Biol. Trace Elem. Res. 133, 128–135 (2010).
